Can I read Efficacy of Oral Sotalol in Reentrant Ventricular Tachycardia on EtoBox?

Efficacy of Oral Sotalol in Reentrant Ventricular Tachycardia by I. W. P. Obel; R. Jardine; B. Haitus; R. N. Scott Millar is a Medicine article available to read on EtoBox.

What is Efficacy of Oral Sotalol in Reentrant Ventricular Tachycardia about?

Oral sotalol was given to 64 patients (78% postinfarction) with recurrent, reentrant ventricular tachycardia (VT) during an average follow-up period of 19.7 months. Fifty-nine (92%) patients had previously experienced recurrent ventricular tachycardia, in spite of having received an average of three conventional antiarrhythmic drugs (13 had previously failed on other Class III drugs). The nature and mechanism of the VT was proved with electrophysiologic testing (EPS), and the chronic sotalol dosage was determined by repeated EPS at 3- to 4-day intervals until the VT was no longer inducible. Sotalol failed in five patients and was discontinued in six patients because of severe side effects (three proarrhythmic effects, including two with torsades de pointes)--a total of 18%. Sotalol was successful alone in 42 patients (65%) and in combination with another antiarrhythmic drug in 11 patients (18%). The average dose of sotalol required for success was 589 mg; 658 mg was the mean daily dose when given alone and 486 mg when given in combination. Side effects were common and were due mainly to the beta-blocking effects of sotalol. Dual chamber pacing was required by 11 patients because of

Who reads Efficacy of Oral Sotalol in Reentrant Ventricular Tachycardia?

Author

I. W. P. Obel; R. Jardine; B. Haitus; R. N. Scott Millar

Publisher

Springer US; Springer-Verlag; Kluwer Academic Publishers; Springer Science and Business Media LLC (ISSN 0920-3206)

Published

1990

Language

EN

Field

Medicine (Health Sciences)