About this Medicine article
High-dose amphotericin: yay or nay? A case series and literature review by Kayla R Stover; Taylor E Jordan; Jamie L Wagner; Katie E Barber is a Medicine article available to read on EtoBox.
Invasive fungal infections pose significant morbidity and mortality risks, particularly those caused by moulds. Available antifungal classes are limited by toxicities and are increasingly susceptible to resistance, particularly amongst challenging fungal pathogens. The purpose of this case series and literature review was to characterize the use of a high-dose lipid formulation of amphotericin B. A case series is presented including patients who received high-dose lipid formulation amphotericin B (≥7.5 mg/kg/day) between June 2012 and August 2021. Additionally, a systematic literature review was conducted by searching the PubMed database for English-language studies involving individuals who received high-dose amphotericin B therapy (≥7.5 mg/kg) using lipid formulations. Nine patients were included in the case series, receiving an average of 8.9 ± 1.3 mg/kg liposomal amphotericin B over a mean of 11.0 ± 10.8 days predominantly for mould infections including Mucorales, aspergillosis and __Fusarium__. The patients were primarily cared for in intensive care units, with varying treatment histories and outcomes. A total of 11 studies (__n__=260 patients) met inclusion criteria for the l
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Kayla R Stover; Taylor E Jordan; Jamie L Wagner; Katie E Barber
- Publisher
- BioExcel Publishing Ltd
- Published
- 2024
- Language
- EN
- Field
- Medicine (Health Sciences)