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Can I read Ticagrelor Attenuates the Increase of Extracellular Vesicle Concentrations in Plasma After Acute Myocardial Infarction Compared to Clopidogrel on EtoBox?
Ticagrelor Attenuates the Increase of Extracellular Vesicle Concentrations in Plasma After Acute Myocardial Infarction Compared to Clopidogrel by Aleksandra Gasecka; Rienk Nieuwland; Monika Budnik; Françoise Dignat‐George; Ceren Eyileten; Paul Harrison; Romaric Lacroix; Aurélie Leroyer; Grzegorz Opolski; Kinga Pluta; Edwin van der Pol; Marek Postuła; Pia Siljander; Jolanta M. Siller‐Matula; Krzysztof J. Filipiak is a Medicine article available to read on EtoBox.
What is Ticagrelor Attenuates the Increase of Extracellular Vesicle Concentrations in Plasma After Acute Myocardial Infarction Compared to Clopidogrel about?
## Abstract ## Background Platelet P2Y12 antagonist ticagrelor reduces mortality after acute myocardial infarction (AMI) compared to clopidogrel, but the underlying mechanism is unknown. Because activated platelets, leukocytes, and endothelial cells release proinflammatory and prothrombotic extracellular vesicles (EVs), we hypothesized that the release of EVs is more efficiently inhibited by ticagrelor compared to clopidogrel. ## Objectives We compared EV concentrations and EV procoagulant activity in plasma of patients after AMI treated with ticagrelor or clopidogrel. ## Methods After percutaneous coronary intervention, 60 patients with first AMI were randomized to ticagrelor or clopidogrel. Flow cytometry was used to determine concentrations of EVs from activated platelets (CD61^+^, CD62p^+^), fibrinogen^+^, phosphatidylserine (PS^+^), leukocytes (CD45^+^), endothelial cells (CD31^+^, 146^+^), and erythrocytes (CD235a^+^) in plasma at randomization, after 72 hours and 6 months of treatment. A fibrin generation test was used to determine EV procoagulant activity. ## Results Concentrations of platelet, fibrinogen^+^, PS^+^, leukocyte, and erythrocyte EVs increased 6 months after AM
Who reads Ticagrelor Attenuates the Increase of Extracellular Vesicle Concentrations in Plasma After Acute Myocardial Infarction Compared to Clopidogrel?
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- Author
- Aleksandra Gasecka; Rienk Nieuwland; Monika Budnik; Françoise Dignat‐George; Ceren Eyileten; Paul Harrison; Romaric Lacroix; Aurélie Leroyer; Grzegorz Opolski; Kinga Pluta; Edwin van der Pol; Marek Postuła; Pia Siljander; Jolanta M. Siller‐Matula; Krzysztof J. Filipiak
- Publisher
- Elsevier BV
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)