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Microbiota Composition in the Lower Respiratory Tract Is Associated with Severity in Patients with Acute Respiratory Distress by Influenza by Alejandra Hernández-Terán; Angel E. Vega-Sánchez; Fidencio Mejía-Nepomuceno; Ricardo Serna-Muñoz; Sebastián Rodríguez-Llamazares; Iván Salido-Guadarrama; Jose A. Romero-Espinoza; Cristobal Guadarrama-Pérez; Jose L. Sandoval-Gutierrez; Fernando Campos; Erika N. Mondragón-Rivero; Alejandra Ramírez-Venegas; Manuel Castillejos-López; Norma A. Téllez-Navarrete; Rogelio Pérez-Padilla; Joel A. Vázquez-Pérez is a Medicine article available to read on EtoBox.

What is Microbiota Composition in the Lower Respiratory Tract Is Associated with Severity in Patients with Acute Respiratory Distress by Influenza about?

Abstract Several factors are associated with the severity of the respiratory disease caused by the influenza virus. Although viral factors are one of the most studied, in recent years the role of the microbiota and co-infections in severe and fatal outcomes has been recognized. However, most of the work has focused on the microbiota of the upper respiratory tract (URT), hindering potential insights from the lower respiratory tract (LRT) that may help to understand the role of the microbiota in Influenza disease. In this work, we characterized the microbiota of the LRT of patients with Influenza A using 16S rRNA sequencing. We tested if patients with different outcomes (deceased/recovered) and use of antibiotics differ in their microbial community composition. We found important differences in the diversity and composition of the microbiota between deceased and recovered patients. In particular, we detected a high abundance of opportunistic pathogens such as Granulicatella, in patients either deceased or with antibiotic treatment. Also, we found antibiotic treatment correlated with lower diversity of microbial communities and with lower probability of survival in Influenza A patient

Who reads Microbiota Composition in the Lower Respiratory Tract Is Associated with Severity in Patients with Acute Respiratory Distress by Influenza?

Author

Alejandra Hernández-Terán; Angel E. Vega-Sánchez; Fidencio Mejía-Nepomuceno; Ricardo Serna-Muñoz; Sebastián Rodríguez-Llamazares; Iván Salido-Guadarrama; Jose A. Romero-Espinoza; Cristobal Guadarrama-Pérez; Jose L. Sandoval-Gutierrez; Fernando Campos; Erika N. Mondragón-Rivero; Alejandra Ramírez-Venegas; Manuel Castillejos-López; Norma A. Téllez-Navarrete; Rogelio Pérez-Padilla; Joel A. Vázquez-Pérez

Publisher

Springer Science and Business Media LLC

Published

2023

Language

EN

Field

Medicine (Health Sciences)