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A New Strategy to Estimate Levothyroxine Requirement After Total Thyroidectomy for Benign Thyroid Disease by Vincenzo Di Donna; Mario Giannotti Santoro; Chiara de Waure; Maria Pia Ricciato; Rosa Maria Paragliola; Alfredo Pontecorvi; Salvatore Maria Corsello is a Medicine article available to read on EtoBox.
What is A New Strategy to Estimate Levothyroxine Requirement After Total Thyroidectomy for Benign Thyroid Disease about?
## Background: The current approach for calculating the starting dose of levothyroxine (lt4) after total thyroidectomy is based on the patient's body weight (bw). the aim of the study was to identify the major predictive factors of lt4 requirement and to elaborate a new method to improve the accuracy of the lt4 starting dose after total thyroidectomy. ## Methods: The study consists of two parts. the first part consisted of the retrospective identification of 92 adult patients (retrospective cohort) who had undergone a total thyroidectomy for benign disease and who had begun lt4 treatment at a dose of 1.6 μg/kg/day. adjustments to optimize the lt4 dose were then performed at the post-surgery follow-up on the basis of serum thyrotropin (tsh) levels. the results of this retrospective analysis were used to formulate a nomogram for a proper calculation of the lt4 starting dose that was then used prospectively in the second part of the study on 31 consecutive patients (prospective cohort). ## Results: At the first follow-up, 37 (40%) patients from the retrospective cohort were euthyroid. univariate analysis indicated significant correlations between the optimal dose of lt4 and bw, body m
Who reads A New Strategy to Estimate Levothyroxine Requirement After Total Thyroidectomy for Benign Thyroid Disease?
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- Author
- Vincenzo Di Donna; Mario Giannotti Santoro; Chiara de Waure; Maria Pia Ricciato; Rosa Maria Paragliola; Alfredo Pontecorvi; Salvatore Maria Corsello
- Publisher
- Mary Ann Liebert Inc
- Published
- 2014
- Language
- EN
- Field
- Medicine (Health Sciences)