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The absence of the Isw2p–Itc1p chromatin-remodelling complex induces mating type-specific and Flo11p-independent invasive growth of Saccharomyces cerevisiae by Petra Trachtulcová; Ivana Frýdlová; Ivana Janatová; Jiří Hašek is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract The Isw2p–Itc1p chromatin remodelling complex of __Saccharomyces cerevisiae__ is a member of the ISWI class of ATPases with a nucleosome spacing activity, involved in regulation of expression of a broad spectrum of genes. Its absence causes derepression of a‐specific genes and aberrant morphology in α‐mating type cells. We report here that the deletion of the __ISW2__ gene in the originally non‐invasive BY strain induces mating type‐specific invasive growth strongly affected by nitrogen starvation. Although the Flo11 protein was postulated to be critical for haploid invasive growth, we showed that the invasive growth caused by the __isw2__ and __itc1__ deletions in α‐mating type cells was Flo11p‐independent. This type of invasive growth was proved to be a consequence of the activation of the pheromone response pathway. Our results suggest that Isw2 and Itc1 proteins do not have the same impact on the described phenomenon. Copyright © 2004 John Wiley & Sons, Ltd.

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Author

Petra Trachtulcová; Ivana Frýdlová; Ivana Janatová; Jiří Hašek

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); John Wiley & Sons Inc.; [Chichester]; [New York]: John Wiley & Sons, ©1985-; Wiley; Hindawi Limited (ISSN 0749-503X)

Published

2004

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)