Can I read Poly(I:C) Protects Heart from I/R Injury on EtoBox?

Poly(I:C) Protects Heart from I/R Injury by João Pedro Nunes is a document available to read on EtoBox.

What is Poly(I:C) Protects Heart from I/R Injury about?

The document discusses how pretreating with the synthetic double-stranded RNA poly(I:C), which is a ligand for TLR3, protects the heart from ischemia/reperfusion injury. It was found that poly(I:C) preconditioning reduces infarct size and improves cardiac function by activating the TLR3/PI3K/Akt signaling pathway. This results in downregulation of inflammation and apoptosis. The cardioprotective effects of poly(I:C) preconditioning were abolished when TLR3 was knocked out or when PI3K or Akt were inhibited,

Author

João Pedro Nunes

Language

EN