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This study presents a novel approach to enhance the production of recombinant adeno-associated virus (rAAV) vectors by using serotype-specific replicating AAV helper constructs, which significantly increases the yield of AAV2 vectors. The method involves cotransfection of non-packaging AAV helper constructs with adenovirus, resulting in a yield approximately 20-fold higher than traditional methods, while avoiding the production of replication-competent AAV particles. The findings support the development of

Author

huang.wkang

Language

EN