Can I read Possible Role of CREB in the Stimulation of Oligodendrocyte Precursor Cell Proliferation by Neurotrophin‐3 on EtoBox?

Possible Role of CREB in the Stimulation of Oligodendrocyte Precursor Cell Proliferation by Neurotrophin‐3 by Jamie R. Johnson; Annie K. Chu; Carmen Sato‐Bigbee is a Neuroscience article available to read on EtoBox.

What is Possible Role of CREB in the Stimulation of Oligodendrocyte Precursor Cell Proliferation by Neurotrophin‐3 about?

**Abstract:** We have previously shown that the transcription factor CREB (cyclic AMP‐response element binding protein) could be a mediator of neuronal signals that, coupled to different signal transduction pathways, may play different regulatory roles at specific stages of oligodendrocyte (OLG) development. We have found before that in committed OLGs, CREB activation by phosphorylation can be triggered by β‐adrenergic stimulation and appears to play a role in the induction of OLG differentiation by cyclic AMP. In contrast, in OLG precursor cells, CREB phosphorylation is stimulated by neuroligands that increase calcium levels by a process that involves a mitogen‐activated protein kinase (MAPK)/protein kinase C (PKC) pathway. This observation suggested that at this early developmental stage, CREB could play a role in regulating cell proliferation. In support of this hypothesis, we have now found that a rapid and dramatic stimulation of CREB phosphorylation is one of the earliest events that precedes the increase in cell proliferation that is observed when OLG precursors are treated with neurotrophin‐3 (NT‐3). Experiments in which CREB phosphorylation was investigated in the presence

Who reads Possible Role of CREB in the Stimulation of Oligodendrocyte Precursor Cell Proliferation by Neurotrophin‐3?

Author

Jamie R. Johnson; Annie K. Chu; Carmen Sato‐Bigbee

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0022-3042)

Published

2000

Language

EN

Field

Neuroscience (Life Sciences)