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Can I read Reduced O -GlcNAcylation and tubular hypoxia contribute to the antifibrotic effect of SGLT2 inhibitor dapagliflozin in the diabetic kidney on EtoBox?
Reduced O -GlcNAcylation and tubular hypoxia contribute to the antifibrotic effect of SGLT2 inhibitor dapagliflozin in the diabetic kidney by Hodrea, Judit; Balogh, Dora B; Hosszu, Adam; Lenart, Lilla; Besztercei, Balazs; Koszegi, Sandor; Sparding, Nadja; Genovese, Federica; Wagner, Laszlo J; Szabó, Attila J; Fekete, Andrea is a Medicine article available to read on EtoBox.
What is Reduced O -GlcNAcylation and tubular hypoxia contribute to the antifibrotic effect of SGLT2 inhibitor dapagliflozin in the diabetic kidney about?
Diabetic kidney disease is a worldwide epidemic, and therapies are incomplete. Clinical data suggest that improved renal outcomes by Na^+^-glucose cotransporter 2 inhibitor (SGLT2i) are partly beyond their antihyperglycemic effects; however, the mechanisms are still elusive. Here, we investigated the effect of the SGLT2i dapagliflozin (DAPA) in the prevention of elevated __O__-GlcNAcylation and tubular hypoxia as contributors of renal fibrosis. Type 1 diabetes was induced by streptozotocin in adult male Wistar rats. After the onset of diabetes, rats were treated for 6 wk with DAPA or DAPA combined with losartan (LOS). The effect of hyperglycemia was tested in HK-2 cells kept under normal or high glucose conditions. To test the effect of hypoxia, cells were kept in 1% O~2~ for 2 h. Cells were treated with DAPA or DAPA combined with LOS. DAPA slowed the loss of renal function, mitigated renal tubular injury markers (kidney injury molecule-1 and neutrophil gelatinase-associated lipocalin), and reduced tubulointerstitial fibrosis. DAPA diminished high glucose-induced protein __O__-GlcNAcylation and moderated the tubular response to hypoxia through the hypoxia-inducible factor pathway.
Who reads Reduced O -GlcNAcylation and tubular hypoxia contribute to the antifibrotic effect of SGLT2 inhibitor dapagliflozin in the diabetic kidney?
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- Author
- Hodrea, Judit; Balogh, Dora B; Hosszu, Adam; Lenart, Lilla; Besztercei, Balazs; Koszegi, Sandor; Sparding, Nadja; Genovese, Federica; Wagner, Laszlo J; Szabó, Attila J; Fekete, Andrea
- Publisher
- The American Physiological Society; American Physiological Society (ISSN 0363-6127)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)