Can I read miR-21-3p and miR-192-5p in patients with type 2 diabetic nephropathy on EtoBox?

miR-21-3p and miR-192-5p in patients with type 2 diabetic nephropathy by Kadriye Akpınar; Diler Aslan; Semin Melahat Fenkçi; Vildan Caner is a Medicine article available to read on EtoBox.

What is miR-21-3p and miR-192-5p in patients with type 2 diabetic nephropathy about?

## Objectives: Microribonucleic acids (microrna/mirna/mir-) are predicted to be useful in the early diagnosis, monitoring, and treatment of diabetic nephropathy (dn). we aimed to investigate the relationship of dn to mir-21-3p, mir-29a-3p, mir-29b-3p, mir-29c-3p, mir-126-3p, mir-129-1-3p, mir-137, mir-192-5p, mir-212-3p, and mir-320c. ## Methods: There were 50 healthy controls and 100 patients with type 2 diabetes mellitus (t2dm). the diabetic patients were divided into three subgroups: normal to mildly increased (a1, n=51), moderately increased (a2, n=25), and severely increased (a3, n=24) albuminuria. the biochemical measurements were analysed using roche cobas 8000. the plasma mirnas were analysed using rt-qpcr based on sybr green chemistry. ## Results: The relative expression of mir-21-3p was significantly lower in the (a3 p=0.005, 6.6-fold decrease) and dn (a1 + a3) (p=0.005, 6.6-fold decrease) groups compared to the controls. the relative expression of mir-192-5p was also significantly lower in the dn group (p=0.027, 2.4-fold decrease) compared to the controls. the area under curve value was 0.726 for mir-21-3p and 0.717 for mir-192-5p for distinguishing the dn group from the

Who reads miR-21-3p and miR-192-5p in patients with type 2 diabetic nephropathy?

Author

Kadriye Akpınar; Diler Aslan; Semin Melahat Fenkçi; Vildan Caner

Publisher

Walter de Gruyter GmbH

Published

2022

Language

EN

Field

Medicine (Health Sciences)