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Scoparia Dulcis , a Traditional Antidiabetic Plant, Protects Against Streptozotocin Induced Oxidative Stress and Apoptosis in Vitro and in Vivo by Muniappan Latha; Leelavinothan Pari; Sandhya Sitasawad; Ramesh Bhonde is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract Oxidative stress is implicated in the pathogenesis of diabetic complications. The experiments were performed on normal and experimental male Wistar rats treated with __Scoparia dulcis__ plant extract (SPEt). The effect of SPEt was tested on streptozotocin (STZ) treated Rat insulinoma cell lines (RINm5F cells) and isolated islets in vitro. Administration of an aqueous extract of __Scoparia dulcis__ by intragastric intubation (po) at a dose of 200 mg/kg body weight significantly decreased the blood glucose and lipid peroxidative marker thiobarbituric acid reactive substances (TBARS) with significant increase in the activities of plasma insulin, pancreatic superoxide dismutase (SOD), catalase (CAT), and reduced glutathione (GSH) in streptozotocin diabetic rats at the end of 15 days treatment. Streptozotocin at a dose of 10 μg/mL evoked 6‐fold stimulation of insulin secretion from isolated islets indicating its insulin secretagogue activity. The extract markedly reduced the STZ‐induced lipidperoxidation in RINm5F cells. Further, SPEt protected STZ‐mediated cytotoxicity and nitric oxide (NO) production in RINm5F cells. Treatment of RINm5F cells with 5 mM STZ and 10 μg of SPE

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Author

Muniappan Latha; Leelavinothan Pari; Sandhya Sitasawad; Ramesh Bhonde

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1095-6670)

Published

2004

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)