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Anti-Inflammatory and Anti-Hyperuricemic Effects of Chrysin on a High Fructose Corn Syrup-Induced Hyperuricemia Rat Model via the Amelioration of Urate Transporters and Inhibition of NLRP3 Inflammasome Signaling Pathway by Chang, Yi-Hsien (author);Chiang, Yi-Fen (author);Chen, Hsin-Yuan (author);Huang, Yun-Ju (author);Wang, Kai-Lee (author);Hong, Yong-Han (author);Ali, Mohamed (author);Shieh, Tzong-Ming (author);Hsia, Shih-Min (author) is a Medicine article available to read on EtoBox.

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Hyperuricemia is the main cause of gout and involved in the occurrence of many other diseases such as hyperlipidemia and hypertension correlated with metabolic disorders. Chrysin is a flavonoid compound found naturally in honey, propolis, and mushrooms and has anti-inflammatory and antioxidant effects. However, its mechanism of action is not clear yet. This study investigated the mechanism of chrysin’s anti-hyperuricemic effect in hyperuricemia-induced rats fed with high-fructose corn syrup. Orally administrated chrysin for 28 consecutive days effectively decreased uric acid by inhibiting the activity of xanthine oxidase (XO) in the liver. Moreover, chrysin markedly downregulated the protein expression of uric acid transporter 1 (URAT1) and glucose transporter type 9 (GLUT9) and upregulated the protein expression of organic anion transporter 1 (OAT1) and human ATP-binding cassette subfamily G-2 (ABCG2). In addition, chrysin showed prominent anti-oxidative and inflammatory effects as the malondialdehyde (MDA) and interleukin 1 beta (IL-1β) concentration was reduced in both rat kidney and serum, which aligned with the inhibition of NOD-like receptor family pyrin domain containing 3 (

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Author

Chang, Yi-Hsien (author);Chiang, Yi-Fen (author);Chen, Hsin-Yuan (author);Huang, Yun-Ju (author);Wang, Kai-Lee (author);Hong, Yong-Han (author);Ali, Mohamed (author);Shieh, Tzong-Ming (author);Hsia, Shih-Min (author)

Publisher

MDPI AG

Published

2021

Language

EN

Field

Medicine (Health Sciences)