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Development of Nitrosyl Ruthenium Complex-loaded Lipid Carriers for Topical Administration: Improvement in Skin Stability and in Nitric Oxide Release by Visible Light Irradiation by Franciane Marquele-Oliveira; Danielle Cristine de Almeida Santana; Stephânia Fleury Taveira; Deise Mirella Vermeulen; Anderson Rodrigo Moraes de Oliveira; Roberto Santana da Silva; Renata Fonseca Vianna Lopez is a Chemistry article available to read on EtoBox.
What is Development of Nitrosyl Ruthenium Complex-loaded Lipid Carriers for Topical Administration: Improvement in Skin Stability and in Nitric Oxide Release by Visible Light Irradiation about?
The prominent nitric oxide (NO) donor [Ru(terpy)(bdqi)NO](PF 6 ) 3 has been synthesized and evaluated with respect to noteworthy biological effects due to its NO photorelease, including vascular relaxation and melanoma cell culture toxicity. The potential for delivering NO in therapeutic quantities is tenable since the nitrosyl ruthenium complex (NRC) must first reach the "target tissue" and then release the NO upon stimulus. In this context, NRC-loaded lipid carriers were developed and characterized to further explore its topical administration for applications such as skin cancer treatment. NRC-loaded solid lipid nanoparticles (SLN) and nanostructured lipid carriers were prepared via the microemulsification method, with average diameters of 275 ± 15 nm and 211 ± 31 nm and zeta potentials of -40.7 ± 10.4 mV and -50.0 ± 7.5 mV, respectively. In vitro kinetic studies of NRC release from nanoparticles showed sustained release of NRC from the lipid carriers and illustrated the influence of the release medium and the lyophilization process. Stability studies showed that NO is released from NRC as a function of temperature and time and due to skin contact. The encapsulation of NRC in SL
Who reads Development of Nitrosyl Ruthenium Complex-loaded Lipid Carriers for Topical Administration: Improvement in Skin Stability and in Nitric Oxide Release by Visible Light Irradiation?
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- Author
- Franciane Marquele-Oliveira; Danielle Cristine de Almeida Santana; Stephânia Fleury Taveira; Deise Mirella Vermeulen; Anderson Rodrigo Moraes de Oliveira; Roberto Santana da Silva; Renata Fonseca Vianna Lopez
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0731-7085)
- Published
- 2010
- Language
- EN
- Field
- Chemistry (Physical Sciences)