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Can I read Results and Conclusions of the National Toxicology Program's Rodent Carcinogenicity Studies with Sodium Fluoride on EtoBox?
Results and Conclusions of the National Toxicology Program's Rodent Carcinogenicity Studies with Sodium Fluoride by John R. Bucher; Milton R. Hejtmancik; John D. Toft II; Ronald L. Persing; Scot L. Eustis; Joseph K. Haseman is a Medicine article available to read on EtoBox.
What is Results and Conclusions of the National Toxicology Program's Rodent Carcinogenicity Studies with Sodium Fluoride about?
The U S National Toxicology Program (NTP) has conducted toxicity and carcinogenicity studies with sodium fluoride administered in the drinking water to F344/N rats and B6C3F, mice. The drinking water concentrations used in the 2-year studies were 0, 25, 100, or 175 ppm sodium fluoride (equivalent to 0, I I, 45 or 79 ppm fluoride). Survival and weight gains of rats and mice were not affected by fluoride treatment. Animals receiving sodium fluoride developed effects typical of dental fluorosis, and female rats given I75 ppm had increased osteosclerosis. There were no increases in neoplasms in female rats or in male or female mice that were attributed to sodium fluoride administration. There was equivocal evidence of carcinogenic activity of sodium fluoride in male rats based on the occurrence of a small number of osteosarcomas in treated animals.
Who reads Results and Conclusions of the National Toxicology Program's Rodent Carcinogenicity Studies with Sodium Fluoride?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- John R. Bucher; Milton R. Hejtmancik; John D. Toft II; Ronald L. Persing; Scot L. Eustis; Joseph K. Haseman
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)
- Published
- 1991
- Language
- EN
- Field
- Medicine (Health Sciences)