Can I read Intra-articular Nanodrug Delivery Strategies for Treating Osteoarthritis on EtoBox?
Intra-articular Nanodrug Delivery Strategies for Treating Osteoarthritis by Dongyang Zhou; Fengjin Zhou; Shihao Sheng; Yan Wei; Xiao Chen; Jiacan Su is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Intra-articular Nanodrug Delivery Strategies for Treating Osteoarthritis about?
Osteoarthritis (OA) is characterized by progressive cartilage degeneration. Pharmaceutical intervention remains a main treatment approach. However, drug delivery via intra-articular administration (IA) can be restricted by rapid clearance, the dense and highly negatively charged extracellular matrix (ECM) of cartilage, and uneven distribution of diseased chondrocytes. Nanodrug delivery systems, such as liposomes, micelles, and nanoparticles (NPs), have shown great potential to prolong intra-articular residence, penetrate the ECM, and achieve diseased chondrocyte-specific delivery. In this review, we discuss the challenges associated with intra-articular drug delivery in OA and the nanodrug delivery strategies developed to overcome these challenges. It is anticipated that these nanodrug delivery strategies will advance IA of drugs into broader applications in OA treatment.
Who reads Intra-articular Nanodrug Delivery Strategies for Treating Osteoarthritis?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Dongyang Zhou; Fengjin Zhou; Shihao Sheng; Yan Wei; Xiao Chen; Jiacan Su
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)