Opening book details…
Can I read Functional and molecular mapping of uncoupling between vascular permeability and loss of vascular maturation in ovarian carcinoma xenografts: The role of stroma cells in tumor angiogenesis on EtoBox?
Functional and molecular mapping of uncoupling between vascular permeability and loss of vascular maturation in ovarian carcinoma xenografts: The role of stroma cells in tumor angiogenesis by Assaf A. Gilad; Tomer Israely; Hagit Dafni; Gila Meir; Batya Cohen; Michal Neeman is a Medicine article available to read on EtoBox.
What is Functional and molecular mapping of uncoupling between vascular permeability and loss of vascular maturation in ovarian carcinoma xenografts: The role of stroma cells in tumor angiogenesis about?
## Abstract Maintaining homogeneous perfusion in tissues undergoing remodeling and vascular expansion requires tight orchestration of the signals leading to endothelial sprouting and subsequent recruitment of perivascular contractile cells and vascular maturation. This regulation, however, is frequently disrupted in tumors. We previously demonstrated the role of tumor‐associated myofibroblasts in vascularization and exit from dormancy of human ovarian carcinoma xenografts in nude mice. The aim of this work was to determine the contribution of stroma‐ and tumor cell‐derived angiogenic growth factors to the heterogeneity of vascular permeability and maturation in MLS human ovarian carcinoma tumors. We show by RT‐PCR and by __in situ__ hybridization that VEGF was expressed by the tumor cells, while angiopoietin‐1 and ‐2 were expressed only by the infiltrating host stroma cells. Vascular maturation was detected __in vivo__ by vasoreactivity to hypercapnia, measured by BOLD contrast MRI and validated by immunostaining of histologic sections to α‐smooth muscle actin. Vascular permeability was measured __in vivo__ by dynamic contrast‐enhanced MRI using albumin‐based contrast material and
Who reads Functional and molecular mapping of uncoupling between vascular permeability and loss of vascular maturation in ovarian carcinoma xenografts: The role of stroma cells in tumor angiogenesis?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Assaf A. Gilad; Tomer Israely; Hagit Dafni; Gila Meir; Batya Cohen; Michal Neeman
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)
- Published
- 2005
- Language
- EN
- Field
- Medicine (Health Sciences)