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Unique Morphologic and Genetic Characteristics of Acute Myeloid Leukemia with Chromothripsis: a Clinicopathologic Study from a Single Institution by Gao, Juehua; Chen, Yi-Hua; Mina, Alain; Altman, Jessica K.; Kim, Kwang-Youn; Zhang, Yanming; Lu, Xinyan; Jennings, Lawrence; Sukhanova, Madina is a Medicine article available to read on EtoBox.
What is Unique Morphologic and Genetic Characteristics of Acute Myeloid Leukemia with Chromothripsis: a Clinicopathologic Study from a Single Institution about?
Chromothripsis is a unique type of genomic instability and is recognized in various cancers. In myeloid neoplasms (MNs), chromothripsis was linked to poor prognosis and specific genetic alterations (complex karyotype, 5q deletions, and loss of TP53). However, the clinicopathologic features of MNs with chromothripsis have not been thoroughly characterized. We identified chromothripsis in 11 cases of MNs (9 acute myeloid leukemia [AML] and 2 myelodysplastic syndrome [MDS] cases) and noted that all chromothripsis-positive AML cases were AML with myelodysplasia-related changes (AML-MRC). We performed a comparative clinicopathologic and genetic characterization of AML-MRC cases with and without chromothripsis. AML-MRC with chromothripsis is associated with lower white blood cell and platelet counts and higher degree of karyotypic complexity. Chromothripsis in AML-MRC most frequently involves chromosomes 8 and 11 with consequent amplification of either MYC or KMT2A. Comparative morphologic assessment of blast morphology revealed unique features characteristic of AML-MRC with chromothripsis: a variable degree of cytoplasmic vacuolization, granulation, and blebbing. These morphologic marke
Who reads Unique Morphologic and Genetic Characteristics of Acute Myeloid Leukemia with Chromothripsis: a Clinicopathologic Study from a Single Institution?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Gao, Juehua; Chen, Yi-Hua; Mina, Alain; Altman, Jessica K.; Kim, Kwang-Youn; Zhang, Yanming; Lu, Xinyan; Jennings, Lawrence; Sukhanova, Madina
- Publisher
- Elsevier Science; Elsevier ; W. B. Saunders Co., Ltd.; Elsevier BV (ISSN 1532-8392)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)