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Performance of Planar Multisite Microprobes in Recording Extracellular Single-unit Intracortical Activity by K.L. Drake; K.D. Wise; J. Farraye; D.J. Anderson; S.L. BeMent is a Engineering article available to read on EtoBox.

What is Performance of Planar Multisite Microprobes in Recording Extracellular Single-unit Intracortical Activity about?

Abstmt-Multisite microprobes, fabricated using solid-state process technology, offer a new approach with which to investigate the closely-spaced columnar organization of cortical tissue. This paper reports the first detailed analysis of the acute recording capabilities of the planar multisite microprobe. The microprobes consist of a thinfilm electrode array supported by a silicon micromachined substrate and insulated using deposited dielectrics. Microprobes with multiple recording sites spaced from 30 pm to 200 pm apart are used to record spontaneous single-unit activity from rat cerebral cortex. Additionally, a theoretical model is used to establish a basis for interpreting the multisite single-unit data. The results suggest that the microprobes l) couple tightly to the neural tissue with relatively little disturbance to the neural system, 2) facilitate the identification of single units in multiunit records through the use of spatially-separate recording sites, and 3) can be used to detect the cell position in tissue and observe events such as the propagation of electrical activity from the soma to the dendritic tree.

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Author

K.L. Drake; K.D. Wise; J. Farraye; D.J. Anderson; S.L. BeMent

Published

1988

Language

EN

Field

Engineering (Physical Sciences)