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3D structural model of the G‐protein‐coupled cannabinoid CB~2~ receptor by Xiang-Qun Xie; Jian-Zhong Chen; Eric M. Billings is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract The potential for therapeutic specificity in regulating diseases and for reduced side effects has made cannabinoid (CB) receptors one of the most important G‐protein‐coupled receptor (GPCR) targets for drug discovery. The cannabinoid (CB) receptor subtype CB2 is of particular interest due to its involvement in signal transduction in the immune system and its increased characterization by mutational and other studies. However, our understanding of their mode of action has been limited by the absence of an experimental receptor structure. In this study, we have developed a 3D model of the CB2 receptor based on the recent crystal structure of a related GPCR, bovine rhodopsin. The model was developed using multiple sequence alignment of homologous receptor sub‐types in humans and mammals, and compared with other GPCRs. Alignments were analyzed with mutation scores, pairwise hydrophobicity profiles and Kyte‐Doolittle plots. The 3D model of the transmembrane segment was generated by mapping the CB2 sequence onto the homologous residues of the rhodopsin structure. The extra‐ and intracellular loop regions of the CB2 were generated by searching for homologous C~α~ backbone sequ

Who reads 3D structural model of the G‐protein‐coupled cannabinoid CB~2~ receptor?

Author

Xiang-Qun Xie; Jian-Zhong Chen; Eric M. Billings

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); Wiley-Liss Inc; Wiley (ISSN 0887-3585)

Published

2003

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)