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Cisplatin‐loaded Au–Au~2~S nanoparticles for potential cancer therapy: Cytotoxicity, in vitro carcinogenicity, and cellular uptake by Lei Ren; Xiao‐Li Huang; Bin Zhang; Li‐Ping Sun; Qi‐Qing Zhang; Mei‐Chee Tan; Gan‐Moog Chow is a Engineering article available to read on EtoBox.

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## Abstract Cisplatin is one of the most effective cytotoxic agents against cancers. Its usage, however, is limited because of severe resistance and systemic toxicity. A formulation of cisplatin‐loaded Au–Au~2~S nanoparticles (NPs) with near‐IR (NIR) sensitivity is reported to partly overcome this limitation in this paper. NIR sensitive Au–Au~2~S NPs were successfully synthesized by the reduction of tetrachloroauric acid (HAuCl~4~) using sodium sulfide (Na~2~S), and cisplatin was loaded onto Au–Au~2~S NPs via a MUA (11‐mercaptoundecanoic acid) layer. To further investigate the biological safety of cisplatin‐loaded Au–Au~2~S NPs, three different cell lines were used to investigate the acute cytotoxicity and the long‐term potential carcinogenicity __in vitro__. Cisplatin‐loaded Au–Au~2~S NPs were also tested for limited hemocompatibility __in vitro__. Our __in vitro__ short and long‐term data provided preliminary evidence suggesting that cisplatin‐loaded Au–Au~2~S NPs with NIR sensitivity are nontoxic below the maximum recommended dosage. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2008

Who reads Cisplatin‐loaded Au–Au~2~S nanoparticles for potential cancer therapy: Cytotoxicity, in vitro carcinogenicity, and cellular uptake?

Author

Lei Ren; Xiao‐Li Huang; Bin Zhang; Li‐Ping Sun; Qi‐Qing Zhang; Mei‐Chee Tan; Gan‐Moog Chow

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1549-3296)

Published

2007

Language

EN

Field

Engineering (Physical Sciences)