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Can I read Genetic variants in RORA are associated with asthma and allergy markers in an admixed population on EtoBox?
Genetic variants in RORA are associated with asthma and allergy markers in an admixed population by Louise Correia Lima; Gerson de Almeida Queiroz; Ryan dos Santos Costa; Neuza Maria Alcantara-Neves; Cíntia Rodrigues Marques; Gustavo Nunes de Oliveira Costa; Mauricio Lima Barreto; Camila Alexandrina Viana Figueiredo; Valdirene Leão Carneiro is a Immunology and Microbiology article available to read on EtoBox.
What is Genetic variants in RORA are associated with asthma and allergy markers in an admixed population about?
Asthma and allergy affect hundreds of millions of people from childhood to old age. In most of them, the inflammatory process of respiratory allergies involves the participation of type 2 cytokines, derived from T helper-2 (Th2)-cell, and Group 2 Innate Lymphoid (ILC2) Cells. An efficient memory Th2 cell response is dependent on IL-13 produced by ILC2s, causing allergic lung inflammation and elevated serum levels of immunoglobulin E. ILC2 cells are derived from common lymphoid progenitors and their growing depends on the transcription factor RORA. The aim of this work was to identify genetic variants in RORA associated with asthma phenotypes and allergy markers. Genomic DNA samples of 1246 individuals participating from Social Changes Asthma and Allergy in Latin America Program (SCAALA) have been genotyped using Illumina Human 2.5 Omni Beadchip. Logistics regressions have been performed to analyze the association among RORA variants and asthma, skin prick tests (SPT), specific IgE and type 2 cytokine production. Twelve single nucleotide variants (SNVs) were significantly associated with atopy (P < 0.01), in which four of them, rs10162630, rs17191519, rs17270243, and rs55796775 and
Who reads Genetic variants in RORA are associated with asthma and allergy markers in an admixed population?
It is typically read by researchers, students, and practitioners in Immunology and Microbiology.
- Author
- Louise Correia Lima; Gerson de Almeida Queiroz; Ryan dos Santos Costa; Neuza Maria Alcantara-Neves; Cíntia Rodrigues Marques; Gustavo Nunes de Oliveira Costa; Mauricio Lima Barreto; Camila Alexandrina Viana Figueiredo; Valdirene Leão Carneiro
- Publisher
- Elsevier Science; Elsevier ; Elsevier Inc.; Elsevier BV (ISSN 1043-4666)
- Published
- 2018
- Language
- EN
- Field
- Immunology and Microbiology (Life Sciences)