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Can I read Peripheral markers of thyroid function: the effect of T~4~ monotherapy vs T~4~/T~3~ combination therapy in hypothyroid subjects in a randomized crossover study on EtoBox?
Peripheral markers of thyroid function: the effect of T~4~ monotherapy vs T~4~/T~3~ combination therapy in hypothyroid subjects in a randomized crossover study by Ulla Schmidt; Birte Nygaard; Ebbe Winther Jensen; Jan Kvetny; Anne Jarløv; Jens Faber is a Medicine article available to read on EtoBox.
What is Peripheral markers of thyroid function: the effect of T~4~ monotherapy vs T~4~/T~3~ combination therapy in hypothyroid subjects in a randomized crossover study about?
## Background A recent randomized controlled trial suggests that hypothyroid subjects may find levothyroxine (l-T~4~) and levotriiodothyronine combination therapy to be superior to l-T~4~ monotherapy in terms of quality of life, suggesting that the brain registered increased T~3~ availability during the combination therapy. ## Hypothesis Peripheral tissue might also be stimulated during T~4~/T~3~ combination therapy compared with T~4~ monotherapy. ## Methods Serum levels of sex hormone-binding globulin (SHBG), pro-collagen-1-N-terminal peptide (PINP), and N-terminal pro-brain natriuretic peptide (NT-proBNP) (representing hepatocyte, osteoblast, and cardiomyocyte stimulation respectively) were measured in 26 hypothyroid subjects in a double-blind, randomized, crossover trial, which compared the replacement therapy with T~4~/T~3~ in combination (50 μg T~4~ was substituted with 20 μg T~3~) to T~4~ alone (once daily regimens). This was performed to obtain unaltered serum TSH levels during the trial and between the two treatment groups. Blood sampling was performed 24 h after the last intake of thyroid hormone medication. ## Results TSH remained unaltered between the groups ((median) 0.
Who reads Peripheral markers of thyroid function: the effect of T~4~ monotherapy vs T~4~/T~3~ combination therapy in hypothyroid subjects in a randomized crossover study?
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- Author
- Ulla Schmidt; Birte Nygaard; Ebbe Winther Jensen; Jan Kvetny; Anne Jarløv; Jens Faber
- Publisher
- Bioscientifica; BioScientifica Ltd.; [Bristol England]: BioScientifica Ltd., 2012- (ISSN 2049-3614)
- Published
- 2013
- Language
- EN
- Field
- Medicine (Health Sciences)