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Can I read Titanium and Boron Mediated Aldol Reactions of .beta.-Hydroxy Ketones on EtoBox?
Titanium and Boron Mediated Aldol Reactions of .beta.-Hydroxy Ketones by George P. Luke; Joel Morris is a Chemistry article available to read on EtoBox.
What is Titanium and Boron Mediated Aldol Reactions of .beta.-Hydroxy Ketones about?
The reaction of enolates derived from titanium and boron complexes of /?-hydroxy ketones with aldehydes afforded aldol products in good to excellent yields. Whereas the boron mediated reactions gave exclusively anti aldol products derived from the reaction at C,, the titanium mediated reactions produced primarily syn aldol products from reaction at C,,. The product selectivities observed in the titanium mediated aldol reactions were highly dependent on the substitution pattern of the starting /?-hydroxy ketone. The aldol reaction is a powerful tool for the stereoselective construction of acyclic mo1ecules.l Numerous approaches have been examined for controlling the stereochemical outcome of the reaction. Strategies for controlling enolate facial selectivity in the reaction with an achiral aldehyde have included the use of chiral auxiliaries? conformational preferences of an enolate derived from a chiral k e t ~n e , ~, ~ and internal metal c h e l a t i ~n . ~. ~ An alternative and previously unexamined means of controlling stereochemistry in the aldol reaction involves the generation and subsequent enolization of a metal (Ti(IV), B) complex 2 derived from a /?-hydroxy ketone 1 and
Who reads Titanium and Boron Mediated Aldol Reactions of .beta.-Hydroxy Ketones?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- George P. Luke; Joel Morris
- Published
- 1995
- Language
- EN
- Field
- Chemistry (Physical Sciences)