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This study reports on a deep learning algorithm called DeepAcr that was developed to predict anti-CRISPR proteins (Acrs) across different CRISPR-Cas systems. DeepAcr analyzed genomic data and predicted numerous putative Acrs spanning almost all CRISPR-Cas types and subtypes, including over 7,000 putative type IV and VI Acrs not predicted by other algorithms. The researchers then performed a cell-free screen and identified a potent inhibitor of Cas13b nucleases from type VI-B CRISPR-Cas systems, which they n

Author

August Thomasen

Language

EN