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What is JMJD1A about?

The study identifies histone demethylase JMJD1A as a promoter of alternative splicing of androgen receptor variant 7 (AR-V7) in prostate cancer cells, which is linked to resistance to androgen deprivation therapy. JMJD1A enhances the recruitment of splicing factor HNRNPF to AR pre-mRNA, facilitating the generation of AR-V7 while having no effect on full-length androgen receptor (AR-FL). These findings suggest that targeting JMJD1A may offer new therapeutic strategies for treating prostate cancer.

Author

lfanumb

Language

EN