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Inhibition of extracellular signal-regulated kinase 1 by adenovirus mediated small interfering RNA attenuates hepatic fibrosis in rats by Wei Zhong; Wei-Feng Shen; Bei-Fang Ning; Ping-Fang Hu; Yong Lin; Hai-Yan Yue; Chuan Yin; Jun-Liang Hou; Yue-Xiang Chen; Jun-Ping Zhang; Xin Zhang; Wei-Fen Xie is a Medicine article available to read on EtoBox.
What is Inhibition of extracellular signal-regulated kinase 1 by adenovirus mediated small interfering RNA attenuates hepatic fibrosis in rats about?
Extracellular signal-regulated kinase 1 (ERK1) is a critical part of the mitogen-activated protein kinase signal transduction pathway, which is involved in hepatic fibrosis. However, the effect of down-regulation of ERK1 on hepatic fibrosis has not been reported. Here, we induced hepatic fibrosis in rats with dimethylnitrosamine administration or bile duct ligation. An adenovirus carrying small interfering RNA targeting ERK1 (AdshERK1) was constructed to determine its effect on hepatic fibrosis, as evaluated by histological and immunohistochemical examination. Our results demonstrated that AdshERK1 significantly reduced the expression of ERK1 and suppressed proliferation and levels of fibrosis-related genes in hepatic stellate cells in vitro. More importantly, selective inhibition of ERK1 remarkably attenuated the deposition of the extracellular matrix in fibrotic liver in both fibrosis models. In addition, both hepatocytes and biliary epithelial cells were proven to exert the ability to generate the myofibroblasts depending on the insults of the liver, which were remarkably reduced by AdshERK1. Furthermore, up-regulation of ERK1 paralleled the increased expression of transforming
Who reads Inhibition of extracellular signal-regulated kinase 1 by adenovirus mediated small interfering RNA attenuates hepatic fibrosis in rats?
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- Author
- Wei Zhong; Wei-Feng Shen; Bei-Fang Ning; Ping-Fang Hu; Yong Lin; Hai-Yan Yue; Chuan Yin; Jun-Liang Hou; Yue-Xiang Chen; Jun-Ping Zhang; Xin Zhang; Wei-Fen Xie
- Publisher
- Ovid Technologies (Wolters Kluwer Health)
- Published
- 2009
- Language
- EN
- Field
- Medicine (Health Sciences)