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Temporal patterns of broad isoform expression during the development of neuronal lineages in Drosophila by Baohua Zhou; Darren W Williams; Janet Altman; Lynn M Riddiford; James W Truman is a Neuroscience article available to read on EtoBox.

What is Temporal patterns of broad isoform expression during the development of neuronal lineages in Drosophila about?

## Abstract ## Background During the development of the central nervous system (CNS) of __Drosophila__, neuronal stem cells, the neuroblasts (NBs), first generate a set of highly diverse neurons, the primary neurons that mature to control larval behavior, and then more homogeneous sets of neurons that show delayed maturation and are primarily used in the adult. These latter, 'secondary' neurons show a complex pattern of expression of __broad__, which encodes a transcription factor usually associated with metamorphosis, where it acts as a key regulator in the transitions from larva and pupa. ## Results The Broad-Z3 (Br-Z3) isoform appears transiently in most central neurons during embryogenesis, but persists in a subset of these cells through most of larval growth. Some of the latter are embryonic-born secondary neurons, whose development is arrested until the start of metamorphosis. However, the vast bulk of the secondary neurons are generated during larval growth and bromodeoxyuridine incorporation shows that they begin expressing Br-Z3 about 7 hours after their birth, approximately the time that they have finished outgrowth to their initial targets. By the start of metamorphosis,

Who reads Temporal patterns of broad isoform expression during the development of neuronal lineages in Drosophila?

Author

Baohua Zhou; Darren W Williams; Janet Altman; Lynn M Riddiford; James W Truman

Publisher

BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2006-; Springer Science and Business Media LLC (ISSN 1749-8104)

Published

2009

Language

EN

Field

Neuroscience (Life Sciences)