Can I read Separating Function from Structure in Perfusion Imaging of the Aging Brain on EtoBox?

Separating Function from Structure in Perfusion Imaging of the Aging Brain by Iris Asllani; Christian Habeck; Ajna Borogovac; Truman R. Brown; Adam M. Brickman; Yaakov Stern is a Neuroscience article available to read on EtoBox.

What is Separating Function from Structure in Perfusion Imaging of the Aging Brain about?

## Abstract The accuracy of cerebral blood flow (CBF) imaging in humans has been impeded by the partial volume effects (PVE), which are a consequence of the limited spatial resolution. Because of brain atrophy, PVE can be particularly problematic in imaging the elderly and can considerably overestimate the CBF difference with the young. The primary goal of this study was to separate the structural decline from the true CBF reduction in elderly. To this end, a PVE‐correction algorithm was applied on the CBF images acquired with spin‐echo EPI continuous arterial spin labeling MRI (voxel size = 3.4 × 3.4 × 8 mm^3^). Tissue‐specific CBF images that were independent of voxels' tissue fractional volume were obtained in elderly (__N__ = 30) and young (__N__ = 26); mean age difference was 43 years. Globally, PVE‐corrected gray matter CBF was 88.2 ± 16.1 and 107.3 ± 17.5 mL/100 g min^−1^ in elderly and young, respectively. The largest PVE contribution was found in the frontal lobe and accounted for an additional 10% and 12% increase in the age‐related CBF difference between men and women, respectively. The GM‐to‐WM CBF ratios were found to be on average 3.5 in elderly and 3.9 in young. Whol

Who reads Separating Function from Structure in Perfusion Imaging of the Aging Brain?

Author

Iris Asllani; Christian Habeck; Ajna Borogovac; Truman R. Brown; Adam M. Brickman; Yaakov Stern

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 1065-9471)

Published

2009

Language

EN

Field

Neuroscience (Life Sciences)