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Clinical features of patients who present with metastatic prostate carcinoma and serum prostate-specific antigen (PSA) levels < 10 ng/mL : The “PSA negative” patients by Alison J. Birtle; Alex Freeman; John R. W. Masters; Heather A. Payne; Stephen J. Harland; Contributors to the BAUS Section of Oncology Cancer Registry is a Medicine article available to read on EtoBox.

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## Background: Although < 1% of men present with prostate-specific antigen (psa)-negative prostate carcinoma, in that they have serum psa levels much lower than the tumor burden would suggest, such patients represent a management dilemma. to the authors' knowledge, little information exists in the literature regarding patterns of disease and response to treatment. the authors wished to define the clinical features of this patient group. ## Methods: The british association of urological surgeons cancer registry 2000 and 2001 data bases were used to identify the clinical features and outcome of 33 men with metastatic prostate carcinoma who presented with serum psa levels < 10 ng/ml. clinical notes and histopathology were reviewed for each patient. ## Results: Seventeen patients (51%) presented with urinary symptoms and/or pelvic pain, 6% with cachexia and 21% with bone pain. characteristic bone metastases were present in 81% of patients, similar to the presentation of men with high serum psa levels. hypercalcemia was a feature in 9% of patients. visceral metastases were present in two patients. the median response duration to first-line hormone manipulation was 7 months. no responses

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Author

Alison J. Birtle; Alex Freeman; John R. W. Masters; Heather A. Payne; Stephen J. Harland; Contributors to the BAUS Section of Oncology Cancer Registry

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0008-543X)

Published

2003

Language

EN

Field

Medicine (Health Sciences)