Can I read Type III and Type IV hypersensitivity reactions due to mitomycin C on EtoBox?

Type III and Type IV hypersensitivity reactions due to mitomycin C by Lia Kunkeler; Cees Nieboer; Derk P. Bruynzeel is a Medicine article available to read on EtoBox.

What is Type III and Type IV hypersensitivity reactions due to mitomycin C about?

A 71‐year‐old man developed an exfoliative dermatitis of the palms of the hands and soles of the feet, and a generalized itch, during treatment with intravesical instillations of mitomycin C for an undifferentiated carcinoma of the bladder. Patch tests with mitomycin C 0.03%, 0.1% and 0.3% aq. were positive. Because of the serious consequences of this finding, the patient was retested with mitomycin C in pet. (same concentrations), a more stable preparation. This showed clear positive reactions. During this last series of patch tests, he developed palpable purpura on the legs. We postulated that this reaction was an immune‐complex‐mediated reaction, caused by the 2nd series of patch tests with mitomycin C. To prove this, we performed histopathological and immunofluorescense investigations, and these showed the reaction to be consistent with Henoch‐Schönlein‐type purpura. We therefore conclude that this patient developed systemic reactions to mitomycin C, characterized by an eczematous dermatitis as well as purpuric reactions. The intravesical installations with mitomycin C have been stopped. The patient's skin problems (the purpura as well as the eczema) have completely resolved an

Who reads Type III and Type IV hypersensitivity reactions due to mitomycin C?

Author

Lia Kunkeler; Cees Nieboer; Derk P. Bruynzeel

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0105-1873)

Published

2000

Language

EN

Field

Medicine (Health Sciences)