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What is Mechanism of DNA Ligase Nick Recognition about?

(1) DNA ligases are enzymes that repair single and double stranded breaks in DNA. They do this through a three step mechanism of adenylation, nick binding, and phosphodiester bond formation. (2) DNA ligases and DNA polymerases share structural similarities, with two core domains connected by a flexible linker. Domain 1 contains the active site and domain 2 helps bind DNA. (3) The document proposes a mechanism where DNA ligase induces a transition of bound DNA from B-form to strained A/B-form, causing co

Author

Anuvansh Singh

Language

EN