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Changes in thymic export of L‐selectin^+^ γδ and αβ T cells during fetal and postnatal development by Deborah A. Witherden; Nevin J. Abernethy; Wayne G. Kimpton; Ross N. P. Cahill is a Immunology and Microbiology article available to read on EtoBox.

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## Abstract We have used the technique of __in situ__ intrathymic injection of fluorescein isothiocyanate to examine L‐selectin expression on γδ and αβ T cells immediately after emigrating from the thymus of fetal and postnatal animals. We found that the percentage of L‐selectin^+^ thymocytes exported per day decreased by half after birth and that the export of T cells from the thymus does not rely on expression of the peripheral lymph node homing receptor, L‐selectin. Analysis of L‐selectin on emigrant and mature T cell subsets revealed a remarkable heterogeneity of expression, both in terms of the numbers of cells expressing this molecule as well as the level of expression. γδ T cells, reportedly not having a propensity for homing to lymph nodes, not only contained the highest proportion of L‐selectin^+^ cells, but also expressed far more of this molecule than either CD4^+^CD8^−^ or CD4^−^CD8^+^ αβ T cells. Furthermore, those emigrant T cells expressing L‐selectin are somewhat immature in their expression of this molecule. Subsequent maturation resulted in up‐regulation of L‐selectin on mature peripheral blood T cells, maturation that was clearly independent of extrinsic antigen.

Who reads Changes in thymic export of L‐selectin^+^ γδ and αβ T cells during fetal and postnatal development?

Author

Deborah A. Witherden; Nevin J. Abernethy; Wayne G. Kimpton; Ross N. P. Cahill

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Ltd.; Wiley (ISSN 0014-2980)

Published

1994

Language

EN

Field

Immunology and Microbiology (Life Sciences)