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Can I read Dimethylfumarate Inhibits Tumor Cell Invasion and Metastasis by Suppressing the Expression and Activities of Matrix Metalloproteinases in Melanoma Cells on EtoBox?
Dimethylfumarate Inhibits Tumor Cell Invasion and Metastasis by Suppressing the Expression and Activities of Matrix Metalloproteinases in Melanoma Cells by Yuzuru Yamazoe; Masanobu Tsubaki; Hiroshi Matsuoka; Takao Satou; Tatsuki Itoh; Takashi Kusunoki; Yasuhiro Kidera; Yoshihiro Tanimori; Kaori Shoji; Haruyuki Nakamura; Mitsuhiko Ogaki; Saori Nishiura; Shozo Nishida is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Dimethylfumarate Inhibits Tumor Cell Invasion and Metastasis by Suppressing the Expression and Activities of Matrix Metalloproteinases in Melanoma Cells about?
## Abstract NF‐κB acts as a signal transducer during tumor progression, cell invasion, and metastasis. Dimethylfumarate (DMF) is reported to inhibit tumor necrosis factor‐α‐induced nuclear entry of NF‐κB/p65. However, only a few reports suggest that DMF inhibits tumor metastasis; also the molecular mechanisms underlying the inhibition of metastasis are poorly understood. We investigated the inhibition of tumor invasion and metastasis by DMF in a melanoma cell line, B16BL6. DMF inhibited B16BL6 cell invasion and metastasis by suppressing the expression and activities of MMPs. DMF also inhibited the nuclear entry of NF‐κB/p65, thus inhibiting B16BL6 cell invasion and metastasis. These results suggest that DMF is potentially useful as an anti‐metastatic agent for the treatment of malignant melanoma.
Who reads Dimethylfumarate Inhibits Tumor Cell Invasion and Metastasis by Suppressing the Expression and Activities of Matrix Metalloproteinases in Melanoma Cells?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Yuzuru Yamazoe; Masanobu Tsubaki; Hiroshi Matsuoka; Takao Satou; Tatsuki Itoh; Takashi Kusunoki; Yasuhiro Kidera; Yoshihiro Tanimori; Kaori Shoji; Haruyuki Nakamura; Mitsuhiko Ogaki; Saori Nishiura; Shozo Nishida
- Publisher
- Elsevier Science; Wiley (John Wiley & Sons); Wiley-Blackwell; Wiley (ISSN 1065-6995)
- Published
- 2009
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)