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Outcome and prognostic factors of 391 Japanese patients with primary sclerosing cholangitis by Atsushi Tanaka; Yoriyuki Takamori; Gotaro Toda; Saburo Ohnishi; Hajime Takikawa is a Medicine article available to read on EtoBox.

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## Abstract **Objectives:** We performed a national survey in 2003, and demonstrated characteristic features of primary sclerosing cholangitis (PSC) patients in Japan. In this study, we aimed to clarify the outcome and prognostic factors of Japanese PSC patients. **Methods:** Questionnaires were sent to gastroenterologists in Japan, and 391 patients with PSC were registered and enrolled in the current study. The median follow‐up was 5.3 years (range 0.1–20.8 years). The cumulative incidence for survival was analysed using the Kaplan–Meier method. Univariate and multivariate analyses were performed using the Cox‐proportional hazards regression model for determining prognostic variables. **Results:** The estimated median survival of all patients was 13.1 years, with a 5‐year survival rate of 74.5%. Thirty‐eight patients (9.7%) who underwent liver transplantation (LT) had a 5‐year survival rate of 92.0%. Both univariate and multivariate analysis demonstrated that younger age [below 49 years old; odds ratio (OR)=1.76, 1.12–2.76, __P__=0.0136] and lower total bilirubin (below 3.0 mg/dl; OR=2.50, 1.60–3.89, __P__≤0.0001) were independent prognostic factors for LT‐free survival of PSC

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Author

Atsushi Tanaka; Yoriyuki Takamori; Gotaro Toda; Saburo Ohnishi; Hajime Takikawa

Publisher

Wiley

Published

2008

Language

EN

Field

Medicine (Health Sciences)