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This study investigates the role of TGFβ-activated kinase 1 (TAK1) in regulating necroptotic and apoptotic signaling pathways, revealing that TAK1 functions through both NFκB-dependent and -independent mechanisms. Inhibition of TAK1 enhances TNFα-induced cell death by promoting the activation of caspase 8 and necrosome formation, with key roles identified for adaptor proteins TRADD and deubiquitinase CYLD. The findings suggest that targeting components of the necroptotic pathway may offer new therapeutic st

Author

jxcantab

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EN