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CDD Is 2016294 A by jxcantab is a document available to read on EtoBox.
This study investigates the role of TGFβ-activated kinase 1 (TAK1) in regulating necroptotic and apoptotic signaling pathways, revealing that TAK1 functions through both NFκB-dependent and -independent mechanisms. Inhibition of TAK1 enhances TNFα-induced cell death by promoting the activation of caspase 8 and necrosome formation, with key roles identified for adaptor proteins TRADD and deubiquitinase CYLD. The findings suggest that targeting components of the necroptotic pathway may offer new therapeutic st
- Author
- jxcantab
- Language
- EN