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High sucrose consumption decouples intrinsic and synaptic excitability of AgRP neurons without altering body weight by Austin C. Korgan; Klausen Oliveira-Abreu; Wei Wei; Sophie L. A. Martin; Zoey J. D. Bridges; José Henrique Leal-Cardoso; Catherine C. Kaczorowski; Kristen M. S. O’Connell is a Medicine article available to read on EtoBox.
What is High sucrose consumption decouples intrinsic and synaptic excitability of AgRP neurons without altering body weight about?
## Background/Objective As the obesity epidemic continues, the understanding of macronutrient influence on central nervous system function is critical for understanding diet-induced obesity and potential therapeutics, particularly in light of the increased sugar content in processed foods. Previous research showed mixed effects of sucrose feeding on body weight gain but has yet to reveal insight into the impact of sucrose on hypothalamic functioning. Here, we explore the impact of liquid sucrose feeding for 12 weeks on body weight, body composition, caloric intake, and hypothalamic AgRP neuronal function and synaptic plasticity. ## Methods Patch-clamp electrophysiology of hypothalamic AgRP neurons, metabolic phenotyping and food intake were performed on C57BL/6J mice. ## Results While mice given sugar-sweetened water do not gain significant weight, they do show subtle differences in body composition and caloric intake. When given sugar-sweetened water, mice show similar alterations to AgRP neuronal excitability as in high-fat diet obese models. Increased sugar consumption also primes mice for increased caloric intake and weight gain when given access to a HFD. ## Conclusions Our re
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- Author
- Austin C. Korgan; Klausen Oliveira-Abreu; Wei Wei; Sophie L. A. Martin; Zoey J. D. Bridges; José Henrique Leal-Cardoso; Catherine C. Kaczorowski; Kristen M. S. O’Connell
- Publisher
- Springer Science and Business Media LLC
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)