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Comprehensive Development in Organ-On-A-Chip Technology by X. Joseph; V. Akhil; A. Arathi; PV. Mohanan is a Chemistry article available to read on EtoBox.

What is Comprehensive Development in Organ-On-A-Chip Technology about?

The expeditious advancement in the organ on chip technology provided a phase change to the conventional in vitro tests used to evaluate absorption, distribution, metabolism, excretion (ADME) studies and toxicity assessments. The demand for an accurate predictive model for assessing toxicity and reducing the potential risk factors became the prime area of any drug delivery process. Researchers around the globe are welcoming the incorporation of organ-on-a-chips for ADME and toxicity evaluation. Organ-on-a-chip (OOC) is an interdisciplinary technology that evolved as a contemporary in vitro model for the pharmacokinetics and pharmacodynamics (PK-PD) studies of a proposed drug candidate in the pre-clinical phases of drug development. The OOC provides a platform that mimics the physiological functions occurring in the human body. The precise flow control systems and the rapid sample processing makes OOC more advanced than the conventional two-dimensional (2D) culture systems. The integration of various organs as in the multi organs-on-a-chip provides more significant ideas about the time and dose dependant effects occurring in the body when a new drug molecule is administered as part o

Who reads Comprehensive Development in Organ-On-A-Chip Technology?

Author

X. Joseph; V. Akhil; A. Arathi; PV. Mohanan

Publisher

Elsevier BV

Published

2021

Language

EN

Field

Chemistry (Physical Sciences)