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CYP2C19 loss-of-function is associated with increased risk of hypertension in a Hakka population: a case-control study by Nan Cai; Cunren Li; Xianfang Gu; Wenfeng Zeng; Jiawei Zhong; Jingfeng Liu; Guopeng Zeng; Junxing Zhu; Haifeng Hong is a Medicine article available to read on EtoBox.

What is CYP2C19 loss-of-function is associated with increased risk of hypertension in a Hakka population: a case-control study about?

## Background Genetic factors have a certain proportion in the risk factors of hypertension. The purpose was to investigate the relationship of cytochrome P450 2C19 (__CYP2C19__) polymorphisms with hypertension in Hakka population. ## Methods The study included 1,872 hypertensive patients and 1,110 controls. The genotypes of __CYP2C19__ rs4244285 and rs4986893 of all individuals were detected and analyzed. ## Results The genotype and allele distributions of __CYP2C19__ rs4244285 were significantly different between hypertension group and control group. The __CYP2C19__ \*1/\*1 genotype was the most predominant among the subjects (40.8%), followed by the __CYP2C19__ \*1/\*2 genotype (40.5%). The percentage of __CYP2C19__\*1, \*2, and \*3 allele was 64.2%, 30.8%, and 5.0%, respectively. The proportion of intermediate metabolizers (IM) (49.3% vs. 42.9%), poor metabolizers (PM) (14.3% vs. 8.9%) (__P__ < 0.001), and __CYP2C19__\*2 allele (33.8% vs. 25.7%, __P__ < 0.001) in hypertension group was significantly higher than that in control group. Multivariate logistic regression (adjusted for gender, age, smoking, and drinking) indicated that __CYP2C19__ \*1/\*2, \*1/\*3, and \*2/\*2 genoty

Who reads CYP2C19 loss-of-function is associated with increased risk of hypertension in a Hakka population: a case-control study?

Author

Nan Cai; Cunren Li; Xianfang Gu; Wenfeng Zeng; Jiawei Zhong; Jingfeng Liu; Guopeng Zeng; Junxing Zhu; Haifeng Hong

Publisher

Springer Science and Business Media LLC

Published

2023

Language

EN

Field

Medicine (Health Sciences)