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Roles of Perivascular Adipose Tissue in Hypertension and Atherosclerosis by Hengjing Hu; Minerva Garcia-Barrio; Zhi-sheng Jiang; Yuqing Eugene Chen; Lin Chang is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Roles of Perivascular Adipose Tissue in Hypertension and Atherosclerosis about?

Perivascular adipose tissue (PVAT), which is present surrounding most blood vessels, from the aorta to the microvasculature of the dermis, is mainly composed of fat cells, fibroblasts, stem cells, mast cells, and nerve cells. Although the PVAT is objectively present, its physiological and pathological significance has long been ignored. PVAT was considered as a supporting component of blood vessels and a protective cushion to the vessel wall from the neighboring tissues during relaxation and contraction. Nonetheless, further extensive research found that PVAT actively regulates blood vessel tone through PVAT-derived vasoactive factors, including both relaxing and contracting factors. In addition, PVAT contributes to atherosclerosis through paracrine secretion of a large number of bioactive factors such as adipokines and cytokines. Thereby, PVAT regulates the functions of blood vessels through various mechanisms operating directly on PVAT or on the underlying vessel layers, including vascular smooth muscle cells (VSMCs) and endothelial cells (ECs). PVAT is a unique adipose tissue that plays an essential role in maintaining the vascular structure and regulating vascular function and

Who reads Roles of Perivascular Adipose Tissue in Hypertension and Atherosclerosis?

Author

Hengjing Hu; Minerva Garcia-Barrio; Zhi-sheng Jiang; Yuqing Eugene Chen; Lin Chang

Publisher

Mary Ann Liebert; Mary Ann Liebert Inc.; Mary Ann Liebert Inc (ISSN 1523-0864)

Published

2021

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)