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Effects of Macromolecular Crowding on Protein Folding by Chris McMahon is a document available to read on EtoBox.
What is Effects of Macromolecular Crowding on Protein Folding about?
Crowding induces protein compaction and decreases folding cooperativity. Using discrete molecular dynamics simulations, the authors investigate how macromolecular crowding affects the thermodynamic and folding properties of proteins. They find that crowding induces higher compaction of proteins but makes folding less cooperative by creating alternative non-native conformations that act as barriers to folding in crowded environments.
- Author
- Chris McMahon
- Language
- EN