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Association of Increased Basement Membrane Invasiveness with Absence of Estrogen Receptor and Expression of Vimentin in Human Breast Cancer Cell Lines by Erik W. Thompson; Soonmyoung Paik; Nils Brünner; Connie L. Sommers; Gerhard Zugmaier; Robert Clarke; Thomas B. Shima; Jeffrey Torri; Steven Donahue; Marc E. Lippman; George R. Martin; Robert B. Dickson is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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Lack of estrogen receptor (ER) and presence of vimentin (VIM) associate with poor prognosis in human breast cancer. We have explored the relationships between ER, VIM, and invasiveness in human breast cancer cell lines. In the matrigel outgrowth assay, ER+/VIM-(MCF-7, T47D, ZR-75-1), and ER-/VIM-(MDA-MB-468, SK-Br-3) cell lines were uninvasive, while ER-/VIM+ (BT549, MDA-MB-231, MDA-MB-435, MDA-MB-436, Hs578T) lines formed invasive, penetrating colonies. Similarly, ER-/VIM+ cell lines were significantly more invasive than either the ER+/VIM-or ER-/VIM-cell lines in the Boyden chamber chemoinvasion assay. lnvasive activity in nude mice was only seen with ER-/ VIM+ cell lines MDA-MB-231, MDA-MB-435 and MDA-MB-436. Hs578T cells (ER-/VIM+) showed hematogenous dissemination to the lungs in one of five mice, but lacked local invasion. The ER-/VIM+ MCF-7, , , subline was significantly more active than the MCF-7 cells in vitro, but resembled the wild-type MCF-7 parent in in vivo activity. Data from these cell lines suggest that human breast cancer progression results first in the loss of ER, and subsequently in VIM acquisition, the latter being associated with increased metastatic potentia

Who reads Association of Increased Basement Membrane Invasiveness with Absence of Estrogen Receptor and Expression of Vimentin in Human Breast Cancer Cell Lines?

Author

Erik W. Thompson; Soonmyoung Paik; Nils Brünner; Connie L. Sommers; Gerhard Zugmaier; Robert Clarke; Thomas B. Shima; Jeffrey Torri; Steven Donahue; Marc E. Lippman; George R. Martin; Robert B. Dickson

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0021-9541)

Published

1992

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)