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Can I read Prophylaxis of Posterior Capsule Opacification Through Autophagy Activation with Indomethacin-eluting Intraocular Lens on EtoBox?
Prophylaxis of Posterior Capsule Opacification Through Autophagy Activation with Indomethacin-eluting Intraocular Lens by Xiaobo Zhang; Jing Wang; Jingwei Xu; Wen Xu; Yin Zhang; Chenqi Luo; Shuang Ni; Haijie Han; Xingchao Shentu; Juan Ye; Jian Ji; Ke Yao is a Engineering article available to read on EtoBox.
What is Prophylaxis of Posterior Capsule Opacification Through Autophagy Activation with Indomethacin-eluting Intraocular Lens about?
Posterior capsule opacification (PCO) is the most common long-term postoperative complication of cataract surgery, leading to secondary vision loss. Optimized intraocular lens (IOL) structure and appropriate pharmacological intervention, which provides physical barriers and biological inhibition, respectively, can block the migration, proliferation, and epithelial-mesenchymal transition (EMT) of lens epithelial cells (LECs) for PCO prophylaxis. Herein, a novel indomethacin-eluting IOL (INDOM-IOL) with an optimized sharper edge and a sustained drug release behavior was developed for PCO prevention. Indomethacin (INDOM), an ophthalmic non-steroidal anti-inflammatory drug (NSAID) used for postoperative ocular inflammation, was demonstrated to not only be able to suppress cell migration and down-regulate the expression of cyclooxygenase-2 (COX-2) and EMT markers, including alpha-smooth muscle actin (α-SMA) and cyclin D1, but also promote the autophagy activation in LECs. Additionally, autophagy was also verified to be a potential therapeutic target for the down-regulation of EMT in LECs. The novel IOL, serving as a drug delivery platform, could carry an adjustable dose of hydrophobic i
Who reads Prophylaxis of Posterior Capsule Opacification Through Autophagy Activation with Indomethacin-eluting Intraocular Lens?
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- Xiaobo Zhang; Jing Wang; Jingwei Xu; Wen Xu; Yin Zhang; Chenqi Luo; Shuang Ni; Haijie Han; Xingchao Shentu; Juan Ye; Jian Ji; Ke Yao
- Publisher
- Elsevier BV
- Published
- 2022
- Language
- EN
- Field
- Engineering (Physical Sciences)