Opening book details…
Can I read Picolinic Acid, a Tryptophan Oxidation Product, Does Not Impact Bone Mineral Density but Increases Marrow Adiposity on EtoBox?
Picolinic Acid, a Tryptophan Oxidation Product, Does Not Impact Bone Mineral Density but Increases Marrow Adiposity by Kehong Ding; Meghan E. McGee-Lawrence; Helen Kaiser; Anuj K. Sharma; Jessica L. Pierce; Debra L. Irsik; Wendy B. Bollag; Jianrui Xu; Qing Zhong; William Hill; Xing-Ming Shi; Sadanand Fulzele; Eileen J. Kennedy; Mohammed Elsalanty; Mark W. Hamrick; Carlos M. Isales is a Medicine article available to read on EtoBox.
What is Picolinic Acid, a Tryptophan Oxidation Product, Does Not Impact Bone Mineral Density but Increases Marrow Adiposity about?
Tryptophan is an essential amino acid catabolized initially to kynurenine (kyn), an immunomodulatory metabolite that we have previously shown to promote bone loss. Kyn levels increase with aging and have also been associated with neurodegenerative disorders. Picolinic acid (PA) is another tryptophan metabolite downstream of kyn. However, in contrast to kyn, PA is reported to be neuroprotective and further, to promote osteogenesis in vitro. Thus, we hypothesized that PA might be osteoprotective in vivo. In an IACUC-approved protocol, we fed PA to aged (23-month-old) C57BL/6 mice for eight weeks. In an effort to determine potential interactions of PA with dietary protein we also fed PA in a low-protein diet (8%). The mice were divided into four groups: Control (18% dietary protein), +PA (700 ppm); Low-protein (8%), +PA (700 ppm). The PA feedings had no impact on mouse weight, body composition or bone density. At sacrifice bone and stem cells were collected for analysis, including μCT and RT-qPCR. Addition of PA to the diet had no impact on trabecular bone parameters. However, marrow adiposity was significantly increased in PA-fed mice, and in bone marrow stromal cells isolated from t
Who reads Picolinic Acid, a Tryptophan Oxidation Product, Does Not Impact Bone Mineral Density but Increases Marrow Adiposity?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Kehong Ding; Meghan E. McGee-Lawrence; Helen Kaiser; Anuj K. Sharma; Jessica L. Pierce; Debra L. Irsik; Wendy B. Bollag; Jianrui Xu; Qing Zhong; William Hill; Xing-Ming Shi; Sadanand Fulzele; Eileen J. Kennedy; Mohammed Elsalanty; Mark W. Hamrick; Carlos M. Isales
- Publisher
- Elsevier Science; Elsevier ; Elsevier BV (ISSN 0531-5565)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)