Opening book details…
Can I read Mobility test to assess functional vision in dark-adapted patients with Leber congenital amaurosis on EtoBox?
Mobility test to assess functional vision in dark-adapted patients with Leber congenital amaurosis by Alejandro J. Roman; Artur V. Cideciyan; Vivian Wu; Abraham A. Mascio; Arun K. Krishnan; Alexandra V. Garafalo; Samuel G. Jacobson is a Medicine article available to read on EtoBox.
What is Mobility test to assess functional vision in dark-adapted patients with Leber congenital amaurosis about?
## Background Inherited retinal degenerations (IRDs) affect daylight and night vision to different degrees. In the current work, we devise a method to quantify mobility under dark-adapted conditions in patients with severe childhood blindness due to Leber congenital amaurosis (LCA). Mobility thresholds from two different LCA genotypes are compared to dark-adapted vision measurements using the full-field stimulus test (FST), a conventional desktop outcome measure of rod vision. ## Methods A device consisting of vertical LED strips on a plane resembling a beaded curtain was programmed to produce a rectangular pattern target defining a ‘door’ of varying luminance that could appear at one of three positions. Mobility performance was evaluated by letting the subject walk from a fixed starting position ~ 4 m away from the device with instructions to touch the door. Success was defined as the subject touching within the ‘door’ area. Ten runs were performed and the process was repeated for different levels of luminance. Tests were performed monocularly in dark-adapted and dilated eyes. Results from LCA patients with the __GUCY2D__ and __CEP290__ genotypes and normal subjects were analyzed
Who reads Mobility test to assess functional vision in dark-adapted patients with Leber congenital amaurosis?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Alejandro J. Roman; Artur V. Cideciyan; Vivian Wu; Abraham A. Mascio; Arun K. Krishnan; Alexandra V. Garafalo; Samuel G. Jacobson
- Publisher
- Springer Science and Business Media LLC
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)