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What is Th1 Cells, IL-18, and Airway Hyperresponsiveness about?

The study investigates the role of T helper 1 (Th1) cells stimulated with ovalbumin and IL-18 in inducing airway hyperresponsiveness (AHR) and lung fibrosis through the production of IFN-␥ and IL-13. It was found that both passive and active Th1 mice developed AHR and airway inflammation upon challenge with ovalbumin and IL-18, with IFN-␥ being crucial for AHR induction while IL-13 primarily contributed to eosinophilic infiltration. The findings suggest that targeting IL-18 may provide a therapeutic approac

Author

fika

Language

EN