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Neutrophil/lymphocyte, Platelet/lymphocyte and Monocyte/lymphocyte Ratios in Patients with Affective Disorders by Yanyan Wei; Junhui Feng; Jinbao Ma; Dongning Chen; Jingxu Chen is a Psychology article available to read on EtoBox.

What is Neutrophil/lymphocyte, Platelet/lymphocyte and Monocyte/lymphocyte Ratios in Patients with Affective Disorders about?

## Objective: There is substantial evidence to support that the alterations in the immune-inflammation system play a crucial role in the pathogenic mechanism of affective disorders. the neutrophil/lymphocyte ratio (nlr), platelet/lymphocyte ratio (plr) and monocyte/lymphocyte ratio (mlr) have been recently investigated as simple, rapid, and inexpensive inflammation markers. the purpose of the research is to use large-scale clinical data to study the difference of the inflammation ratios in first-episode mdd, recurrent mdd, bd depressive episodes and manic episode. ## Methods: A cross-sectional design was applied to retrospectively analyse the data that were extracted from electronic health records. a total of 16,174 chinese affective disorder patients were enrolled in this study, and 6681 healthy subjects served as controls. the differences in the nlr, mlr, plr and whole blood count data among different groups were compared, and the contributing factors for the occurrence of mdd and bd were analysed. ## Results: First-episode and recurrent mdd patients exhibited significantly elevated nlrs and mlrs compared to healthy controls. compared with the mdd patients, the bd patients showed

Who reads Neutrophil/lymphocyte, Platelet/lymphocyte and Monocyte/lymphocyte Ratios in Patients with Affective Disorders?

Author

Yanyan Wei; Junhui Feng; Jinbao Ma; Dongning Chen; Jingxu Chen

Publisher

Elsevier BV

Published

2022

Language

EN

Field

Psychology (Social Sciences)