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Gangliosides in Human Skin Fibroblasts and their Enrichment in the “HURLER Variant” and KRABBE’S Disease by LISELOTTE HOF; REUBEN MATALON; ALBERT DORFMAN is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Gangliosides in Human Skin Fibroblasts and their Enrichment in the “HURLER Variant” and KRABBE’S Disease about?

Structure and quantities of gangliosides in skin fibroblasts derived from normal children and patients with several hereditary diseases are studied. Mono-and disialohematosides are the only gangliosides found. There was a 6-fold increase in lipid-bound neuraminic acid in the HURLER variant Zusammenfassung: Ganglioside in menschlichen Hautfibroblasten und ihre Anreicherung in einer HURLER-Variante und der KRABBEJC//\*?// Krankheit. Menschliche Fibroblastenkulturen, gezüchtet aus Haut-ßiopsien gesunder Kinder, werden mittels Dünnschicht-und Gaschromatographie auf ihren Gehalt an Gangliosiden untersucht. Dabei zeigen sich Mono-und Disialohämatoside (Mono-und Dineuraminoy l lactosylceramide) als die überwiegenden Komponenten des Gangliosidgemischs. Die Fettsäurezusammensetzung dieser Ganglioside ähnelt der der neutralen Glykolipide und umfaßt das ganze Spektrum der n-Qs-bis -C24-Fettsäuren. Zusatz von Kälberserum zum Nährmedium, das bereits 10% fötales Kälberserum enthält, bewirkt einen Anstieg der Lipid-gebundenen Neuramin-and 2.3-fold increase in KRABBE'S diesease as compared to the highest normal cells grown under the same conditions. The addition of calf-serum to the growth medium

Who reads Gangliosides in Human Skin Fibroblasts and their Enrichment in the “HURLER Variant” and KRABBE’S Disease?

Author

LISELOTTE HOF; REUBEN MATALON; ALBERT DORFMAN

Publisher

Walter de Gruyter GmbH

Published

1971

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)