Can I read Miotic Effect and Irritation Potential of Pilocarpine Prodrug Incorporated Into a Submicron Emulsion Vehicle on EtoBox?

Miotic Effect and Irritation Potential of Pilocarpine Prodrug Incorporated Into a Submicron Emulsion Vehicle by Malgorzata Sznitowska; Katarzyna Zurowska-Pryczkowska; Stanislaw Janicki; Tomi Järvinen is a Pharmacology, Toxicology and Pharmaceutics article available to read on EtoBox.

What is Miotic Effect and Irritation Potential of Pilocarpine Prodrug Incorporated Into a Submicron Emulsion Vehicle about?

Pilocarpine prodrug, O,O'-dipivaloyl(1,2-ethylene) bispilocarpic acid diester, was introduced to a submicron emulsion vehicle in a dose equivalent to 0.5% pilocarpine base, and the formulation was studied in albino rabbits using miotic assay. Compared with pilocarpine HCl 0.5% solution delayed and prolonged miosis was observed after application of the prodrug emulsion. AUC(0-6 h) values for the prodrug emulsion and pilocarpine solution were 9252+/-1345 and 6845+/-1967%xmin, respectively. The prodrug was also administered twice daily for 5 days in the form of aqueous solution or submicron emulsion in order to study ocular irritation. Irritation potential of the prodrug was significantly reduced when submicron emulsion was used as a vehicle.

Who reads Miotic Effect and Irritation Potential of Pilocarpine Prodrug Incorporated Into a Submicron Emulsion Vehicle?

Author

Malgorzata Sznitowska; Katarzyna Zurowska-Pryczkowska; Stanislaw Janicki; Tomi Järvinen

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0378-5173)

Published

1999

Language

EN

Field

Pharmacology, Toxicology and Pharmaceutics (Life Sciences)