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The study investigates the excessive secretion of IL-8 by skeletal muscle in type 2 diabetes (T2D) and its impact on angiogenesis, revealing that T2D myotubes impair tube growth compared to nondiabetic myotubes. The findings suggest that elevated IL-8 levels create a microenvironment that reduces capillary density, contributing to insulin resistance and metabolic dysfunction in T2D. The research highlights the potential role of the PI3K signaling pathway and the Tie2 receptor in mediating these effects, emp

Author

Hazel Mae Fabros Victoria

Language

EN